IBook and pdf versions of this material and other PK material is availableĬopyright © 2001-2021 David W. Material on this website should be used for Educational or Self-Study Purposes Only This page was last modified: Friday, 2nd Apr 2021 at 4:54 pm Screenshots are from Phoenix WinNonlin version 8.3.1 March 2021. The Maximum Likelihood Models option is very flexible and a more complete description is beyond the scope of this page.
We are now ready to execute the PK model by clicking on the green arrow at the top. Alternately the user can enter initial estimates after selecting User Supplied Initial Parameter Values. With a simple linear model we can have WinNonlin generate the initial parameter estimates using a curve stripping technique.
Data weighting can be chosen from the Weighting/Dosing Option tab below. The dose can be entered using the Setup > Dosing tab with Use Internal Worksheet checked. Here the bounds are not defined and the initial estimates are set to 1 before being determined during the curve stripping step. The fixef equations provide initial estimates with lower and upper bounds. The typical values are used in population pharmacokinetic analysis. tvV) parameter values to the parameter values (V). The stparm equations map the typical (e.g.
The two deriv and the one urinecpt equation represent the differential equations for the A1, A0 and Aa components of the model. CObs is the observed concentration calculated as A1/V.įigure 8.5.4 Textual Representation of a One Compartment Model after Oral Administration (Phoenix Modeling Language ) If Modeling > Maximum Likelihood Models had been chosen the model could be represented graphically or textually for more flexibility.įigure 8.5.3 Graphical Representation of a One Compartment Model after Oral AdministrationĪa represents the amount in the dose compartment, A1 is the central compartment and A0 the elimination (urine) compartment. A diagram illustrating the model is shown in the right panel. Model 3 represents a one compartment model with no lag time and elimination is by a first order process. Here we have data collected after oral administration. Time to Time and Concentration to Concentration. Under the Setup Tab choose Main to choose the PK model to be use and map the data columns to the correct heading. Select the Data Set > Send To > Modeling > Least-Squares Regression Models > PK Model.įigure 8.5.2 Choosing the Model and Mapping the Data Note the comma is selected as the Field Delimiter. Check Has a header row and Has units in column header. This csv file included a header row with units. Data can be entered using as a new Worksheet or by importing a file such as one in the csv (comma delimited) format.įigure 8.5.1 Importing Data in a csv File Scribd is the worlds largest social reading and publishing site. Access Free Adobe Acrobat 80 User Guide read book online for free. The project name can be changed to be more descriptive. Odbcau10 User Guide - Free ebook download as PDF File (.pdf), Text File (.txt) or /9.
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